Laere Erna, Tee Shiau Foon, Tang Pek Yee
Department of Chemical Engineering, Universiti Tunku Abdul Rahman, Kajang, Malaysia.
Department of Mechatronics and Biomedical Engineering, Universiti Tunku Abdul Rahman, Kajang, Malaysia.
Psychiatry Investig. 2018 Oct;15(10):945-955. doi: 10.30773/pi.2018.07.22. Epub 2018 Sep 19.
The present meta-analysis aimed to analyze the cognitive performance of schizophrenia patients measured by Trail Making Tests (TMT) and the contribution of socio-demographic factors to cognitive impairments.
PubMed and PsycARTICLES databases were searched for the studies published between January 1985 and November 2017. Data were drawn from 19 studies encompassing 1095 patients and 324 controls. The effect size and heterogeneity were assessed with Comprehensive Meta-Analysis version 2 using random-effect model.
Overall, the results showed that the schizophrenia patients performed significantly (p<0.001) worse than healthy controls in both TMT-A and B. However, concurrent substance abuse, clinical status (inpatient or outpatient), duration of education and duration of illness were not associated with cognitive impairment among the schizophrenia patients.
The present meta-analysis confirmed the cognitive processing speed and flexibility of schizophrenia patients were impaired. However, their duration of education, duration of illness and clinical status (inpatient or outpatient) were not the risk factors.
本荟萃分析旨在分析通过连线测验（TMT）测量的精神分裂症患者的认知表现以及社会人口学因素对认知障碍的影响。
检索PubMed和PsycARTICLES数据库中1985年1月至2017年11月发表的研究。数据来自19项研究，包括1095例患者和324例对照。使用随机效应模型，通过综合荟萃分析第2版评估效应量和异质性。
总体而言，结果显示精神分裂症患者在TMT-A和TMT-B中的表现均显著（p<0.001）差于健康对照。然而，同时存在物质滥用、临床状态（住院或门诊）、教育年限和病程与精神分裂症患者的认知障碍无关。
本荟萃分析证实精神分裂症患者的认知加工速度和灵活性受损。然而，他们的教育年限、病程和临床状态（住院或门诊）并非危险因素。
