来自具缘香科塔草的α-吡喃酮和一种2(5H)-呋喃酮。

Alpha-pyrones and a 2(5H)-furanone from Hyptis pectinata.

作者信息

Boalino Dionne M, Connolly Joseph D, McLean Stewart, Reynolds William F, Tinto Winston F

机构信息

Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, PO Box 64, Bridgetown, Barbados.

出版信息

Phytochemistry. 2003 Dec;64(7):1303-7. doi: 10.1016/j.phytochem.2003.08.017.

DOI:10.1016/j.phytochem.2003.08.017

PMID:14599529

Abstract

Three pyrones and a 2(5H)-furanone, designated pectinolides D-G, have been isolated from the dichloromethane extract of Hyptis pectinata. The metabolites were characterized on the basis of 1D and 2D NMR spectroscopic techniques. The pyrones were identified as 6S-[3S,6S-(diacetoxy)-5R-hydroxy-1Z-heptenyl]-5S-hydroxy-5,6-dihydro-2H-pyran-2-one (1)- pectinolide D, 6S-[3S,5R,6S-(triacetoxy)-1Z-heptenyl]-5S-acetoxy-5,6-dihydro-2H-pyran-2-one (2)- pectinolide E and 6S-[3S,5R,6S-(triacetoxy)-1Z-heptenyl]-5S-acetoxy-4R-methoxy-3,4,5,6-tetrahydro-4H pyran-2-one (3)- pectinolide F. The furanone was identified as [2'Z,5(1')Z] 5-(4'S,6'R,7'S-triacetoxy-2-octenylidene)-2(5H)-furanone (4)-pectinolide G.

摘要

从波缘香科（Hyptis pectinata）的二氯甲烷提取物中分离出了三种吡喃酮和一种2(5H)-呋喃酮，分别命名为果胶内酯D-G。这些代谢产物通过一维和二维核磁共振光谱技术进行了表征。吡喃酮被鉴定为6S-[3S,6S-(二乙酰氧基)-5R-羟基-1Z-庚烯基]-5S-羟基-5,6-二氢-2H-吡喃-2-酮（1）-果胶内酯D、6S-[3S,5R,6S-(三乙酰氧基)-1Z-庚烯基]-5S-乙酰氧基-5,6-二氢-2H-吡喃-2-酮（2）-果胶内酯E和6S-[3S,5R,6S-(三乙酰氧基)-1Z-庚烯基]-5S-乙酰氧基-4R-甲氧基-3,4,5,6-四氢-4H-吡喃-2-酮（3）-果胶内酯F。呋喃酮被鉴定为[2'Z,5(1')Z] 5-(4'S,6'R,7'S-三乙酰氧基-2-亚辛烯基)-2(5H)-呋喃酮（4）-果胶内酯G。