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子宫恶性混合性苗勒管肿瘤产生甲胎蛋白。

Alpha-fetoprotein production by a malignant mixed müllerian tumour of the uterus.

作者信息

Phillips K A, Scurry J P, Toner G

机构信息

Department of Haematology and Oncology, Peter MacCallum Hospital, Melbourne.

出版信息

J Clin Pathol. 1996 Apr;49(4):349-51. doi: 10.1136/jcp.49.4.349.

DOI:10.1136/jcp.49.4.349
PMID:8655717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500467/
Abstract

A case of alpha-fetoprotein production by a uterine malignant mixed müllerian tumour is described. The patient was a 68 year old woman who developed intraabdominal recurrence of a stage 1 uterine tumour which had been treated surgically seven years previously. Her serum alpha-fetoprotein was raised at 21,000 micrograms/l (normal < 10 micrograms/l) and staining with immunoperoxidase confirmed that the tumour was the site of alpha-fetoprotein production. The patient was treated with combination chemotherapy but died two weeks after the first course. This is believed to be only the second such case reported.

摘要

本文描述了一例由子宫恶性苗勒管混合瘤产生甲胎蛋白的病例。患者为一名68岁女性，七年前接受手术治疗的Ⅰ期子宫肿瘤出现腹腔内复发。她的血清甲胎蛋白升高至21,000微克/升（正常<10微克/升），免疫过氧化物酶染色证实肿瘤是甲胎蛋白产生的部位。该患者接受了联合化疗，但在第一个疗程后两周死亡。据信这是报告的第二例此类病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af2/500467/d506ba5bd1db/jclinpath00241-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af2/500467/d506ba5bd1db/jclinpath00241-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af2/500467/d506ba5bd1db/jclinpath00241-0080-a.jpg

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α-Fetoprotein-Producing Endometrial Carcinoma Is Associated With Fetal Gut-Like and/or Hepatoid Morphology, Lymphovascular Infiltration, Abnormalities, and Poor Prognosis: Five Cases and Literature Review.产生甲胎蛋白的子宫内膜癌与胎儿肠道样和/或肝样形态、淋巴管浸润、异常及预后不良相关：5例病例及文献综述
Front Med (Lausanne). 2021 Dec 15;8:799163. doi: 10.3389/fmed.2021.799163. eCollection 2021.
3

本文引用的文献

1
Alpha-fetoprotein in cancer.癌症中的甲胎蛋白。
Ann Chir Gynaecol. 1989;78(1):27-31.
2
Hepatoid carcinoma of the ovary. A newly described tumor.卵巢肝样癌。一种新描述的肿瘤。
Cancer. 1987 Dec 1;60(11):2775-84. doi: 10.1002/1097-0142(19871201)60:11<2775::aid-cncr2820601130>3.0.co;2-s.
3
A case of mixed mesodermal tumor of the uterus with alpha-fetoprotein production.一例产生甲胎蛋白的子宫混合性中胚叶肿瘤。
α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component.
无明显肝样成分的产甲胎蛋白子宫内膜腺癌
Oncol Lett. 2010 Mar;1(2):243-245. doi: 10.3892/ol_00000043. Epub 2010 Mar 1.
4
α-fetoprotein produced by endometrioid adenocarcinoma of uterus.子宫子宫内膜样腺癌产生的甲胎蛋白。
BMJ Case Rep. 2012 Jun 25;2012:bcr0220125830. doi: 10.1136/bcr.02.2012.5830.
Jpn J Clin Oncol. 1985 Sep;15(3):577-83.
4
Ovarian mucinous cystadenocarcinoma producing alpha-fetoprotein. A case report.产生甲胎蛋白的卵巢黏液性囊腺癌。病例报告。
Acta Pathol Jpn. 1992 May;42(5):372-5. doi: 10.1111/j.1440-1827.1992.tb02888.x.