Kawaguchi Ryuji, Furukawa Naoto, Yamada Yoshihiko, Ooi Hidekazu, Kobayashi Hiroshi
Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.
Case Rep Oncol. 2011;4(2):358-62. doi: 10.1159/000330239. Epub 2011 Jul 9.
We report two cases of uterine carcinosarcoma associated with alpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma. Samples were obtained from two women aged 63 and 82 years. Serum AFP levels of the two samples were 10,131 and 401 ng/ml, respectively. Histologically, in both cases the tumor cells were composed of hepatoid adenocarcinoma component and sarcoma component including rhabdomyosarcoma. Immunohistochemical analyses revealed that AFP was expressed in the cytoplasm of the carcinomatous component. After surgery, the patients received six courses of carboplatin/paclitaxel chemotherapy, and the serum levels of AFP decreased to normal range. The first patient is alive and well at the 2-year follow-up, while the second patient died of disease 1 year after initial operative treatment. This is, to our knowledge, the second report of carcinosarcoma of the uterine corpus with AFP-producing hepatoid adenocarcinoma, as proven by immunohistochemical analyses.
我们报告了两例与产生甲胎蛋白（AFP）的肝样腺癌相关的子宫癌肉瘤病例。样本取自两名年龄分别为63岁和82岁的女性。这两个样本的血清AFP水平分别为10,131和401 ng/ml。组织学上，在这两个病例中，肿瘤细胞均由肝样腺癌成分和肉瘤成分（包括横纹肌肉瘤）组成。免疫组化分析显示，AFP在癌性成分的细胞质中表达。手术后，患者接受了六个疗程的卡铂/紫杉醇化疗，血清AFP水平降至正常范围。第一名患者在2年随访时存活且状况良好，而第二名患者在初次手术治疗后1年死于疾病。据我们所知，这是经免疫组化分析证实的第二例子宫体癌肉瘤合并产生AFP的肝样腺癌的报告。
