Reid Ann H, Janczewski Thomas A, Lourens Raina M, Elliot Alex J, Daniels Rod S, Berry Colin L, Oxford John S, Taubenberger Jeffery K
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850-3125, USA.
Emerg Infect Dis. 2003 Oct;9(10):1249-53. doi: 10.3201/eid0910.020789.
The “Spanish influenza pandemic swept the globe in the autumn and winter of 1918–19, and resulted in the deaths of approximately 40 million people. Clinically, epidemiologically, and pathologically, the disease was remarkably uniform, which suggests that similar viruses were causing disease around the world. To assess the homogeneity of the 1918 pandemic influenza virus, partial hemagglutinin gene sequences have been determined for five cases, including two newly identified samples from London, United Kingdom. The strains show 98.9% to 99.8% nucleotide sequence identity. One of the few differences between the strains maps to the receptor-binding site of hemagglutinin, suggesting that two receptor-binding configurations were co-circulating during the pandemic. The results suggest that in the early stages of an influenza A pandemic, mutations that occur during replication do not become fixed so that a uniform “consensus” strain circulates for some time.
1918年至1919年秋冬，“西班牙流感”大流行席卷全球，导致约4000万人死亡。在临床、流行病学和病理学上，这种疾病表现出显著的一致性，这表明世界各地的致病病毒相似。为评估1918年大流行流感病毒的同源性，已测定了5个病例的部分血凝素基因序列，其中包括来自英国伦敦的两个新鉴定样本。这些毒株的核苷酸序列同一性为98.9%至99.8%。毒株之间为数不多的差异之一位于血凝素的受体结合位点，这表明在大流行期间两种受体结合构型共同传播。结果表明，在甲型流感大流行的早期阶段，复制过程中发生的突变不会固定下来，因此一种统一的“共识”毒株会传播一段时间。
