Fodor William L
Center for Regenerative Biology and Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06250-4243, USA.
Reprod Biol Endocrinol. 2003 Nov 13;1:102. doi: 10.1186/1477-7827-1-102.
The field of Regenerative Biology as it applies to Regenerative Medicine is an increasingly expanding area of research with hopes of providing therapeutic treatments for diseases and/or injuries that conventional medicines and even new biologic drug therapies cannot effectively treat. Extensive research in the area of Regenerative Medicine is focused on the development of cells, tissues and organs for the purpose of restoring function through transplantation. The general belief is that replacement, repair and restoration of function is best accomplished by cells, tissues or organs that can perform the appropriate physiologic/metabolic duties better than any mechanical device, recombinant protein therapeutic or chemical compound. Several strategies are currently being investigated and include, cell therapies derived from autologous primary cell isolates, cell therapies derived from established cell lines, cell therapies derived from a variety of stem cells, including bone marrow/mesenchymal stem cells, cord blood stem cells, embryonic stem cells, as well as cells tissues and organs from genetically modified animals. This mini-review is not meant to be exhaustive, but aims to highlight clinical applications for the four areas of research listed above and will address a few key advances and a few of the hurdles yet to be overcome as the technology and science improve the likelihood that Regenerative Medicine will become clinically routine.
再生生物学应用于再生医学的领域是一个不断扩展的研究领域，有望为传统药物甚至新的生物药物疗法无法有效治疗的疾病和/或损伤提供治疗方法。再生医学领域的广泛研究集中于开发细胞、组织和器官，以便通过移植恢复功能。人们普遍认为，功能的替代、修复和恢复最好通过能够比任何机械装置、重组蛋白疗法或化合物更好地履行适当生理/代谢职责的细胞、组织或器官来实现。目前正在研究几种策略，包括源自自体原代细胞分离物的细胞疗法、源自已建立细胞系的细胞疗法、源自多种干细胞（包括骨髓/间充质干细胞、脐带血干细胞、胚胎干细胞）的细胞疗法，以及来自基因改造动物的细胞、组织和器官。本综述并非详尽无遗，而是旨在突出上述四个研究领域的临床应用，并将探讨随着技术和科学提高再生医学成为临床常规治疗的可能性，一些关键进展以及一些有待克服的障碍。
