胶原蛋白——结构、功能与生物合成

Collagens--structure, function, and biosynthesis.

作者信息

Gelse K, Pöschl E, Aigner T

机构信息

Cartilage Research, Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstr. 8-10, D-91054 Erlangen, Germany.

出版信息

Adv Drug Deliv Rev. 2003 Nov 28;55(12):1531-46. doi: 10.1016/j.addr.2003.08.002.

DOI:10.1016/j.addr.2003.08.002

PMID:14623400

Abstract

The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified so far. Collagens are centrally involved in the formation of fibrillar and microfibrillar networks of the extracellular matrix, basement membranes as well as other structures of the extracellular matrix. This review focuses on the distribution and function of various collagen types in different tissues. It introduces their basic structural subunits and points out major steps in the biosynthesis and supramolecular processing of fibrillar collagens as prototypical members of this protein family. A final outlook indicates the importance of different collagen types not only for the understanding of collagen-related diseases, but also as a basis for the therapeutical use of members of this protein family discussed in other chapters of this issue.

摘要

细胞外基质是多种蛋白质家族中不同成员的复杂组合，它决定了结构完整性和各种生理功能。目前已鉴定出的最丰富的家族是胶原蛋白家族，其中有20多种不同类型的胶原蛋白。胶原蛋白在细胞外基质的纤维状和微纤维状网络、基底膜以及细胞外基质的其他结构的形成中起着核心作用。本综述重点关注不同类型胶原蛋白在不同组织中的分布和功能。它介绍了它们的基本结构亚基，并指出了作为该蛋白质家族典型成员的纤维状胶原蛋白在生物合成和超分子加工中的主要步骤。最后的展望表明，不同类型的胶原蛋白不仅对于理解与胶原蛋白相关的疾病很重要，而且也是本期其他章节中讨论的该蛋白质家族成员治疗用途的基础。