活性氧物种在冈比亚按蚊中对疟原虫黑化包囊形成的作用。
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae.
作者信息
Kumar Sanjeev, Christophides George K, Cantera Rafael, Charles Bradley, Han Yeon Soo, Meister Stephan, Dimopoulos George, Kafatos Fotis C, Barillas-Mury Carolina
机构信息
Colorado State University, Department of Microbiology, Immunology, and Pathology, 1619 Campus Delivery, Fort Collins, CO 80523, USA.
出版信息
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14139-44. doi: 10.1073/pnas.2036262100. Epub 2003 Nov 17.
Abstract
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks Plasmodium development, melanizing, and encapsulating the parasite in a reaction that begins with tyrosine oxidation, and involves three quantitative trait loci. Morphological and microarray mRNA expression analysis suggest that the refractory and susceptible strains have broad physiological differences, which are related to the production and detoxification of reactive oxygen species. Physiological studies corroborate that the refractory strain is in a chronic state of oxidative stress, which is exacerbated by blood feeding, resulting in increased steady-state levels of reactive oxygen species, which favor melanization of parasites as well as Sephadex beads.
摘要
疟疾传播取决于某些按蚊维持疟原虫发育的能力（易感性）。一种经过基因选择的冈比亚按蚊难治品系会阻断疟原虫的发育，通过酪氨酸氧化引发的反应使寄生虫黑化并被包裹，该反应涉及三个数量性状位点。形态学和微阵列mRNA表达分析表明，难治品系和易感品系存在广泛的生理差异，这与活性氧的产生和解毒有关。生理学研究证实，难治品系处于慢性氧化应激状态，吸血会加剧这种状态，导致活性氧稳态水平升高，这有利于寄生虫以及葡聚糖凝胶珠的黑化。
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