Somani S K, Aggarwal R, Naik S R, Srivastava S, Naik S
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226 014, India.
J Viral Hepat. 2003 Nov;10(6):446-9. doi: 10.1046/j.1365-2893.2003.00458.x.
Intrafamilial transmission is rare in epidemic hepatitis E; its frequency in sporadic hepatitis E is not known. We followed up 86 household contacts (age range 4-75 years, mean +/- SD 32.4 +/- 15.8; 49 males), who were family members of patients with acute sporadic hepatitis E. Of the 86 contacts, 68 (79%) tested negative for IgG anti-hepatitis E virus antibodies. Four (4.7%) had IgM anti-hepatitis E virus antibodies at the time of diagnosis of hepatitis E in the index case; two of these contacts possibly had hepatitis E virus infection acquired simultaneously with that in the index case, and two could have had intrafamilial transmission. None developed serological evidence of hepatitis E virus infection over a period of 49 +/- 18 days after the diagnosis of index case, although a majority lacked IgG antibodies to hepatitis E virus and were likely to be susceptible. This suggests that person-to-person transmission is uncommon in sporadic hepatitis E.
戊型肝炎流行时，家庭内传播很少见；散发性戊型肝炎的传播频率尚不清楚。我们对86名家庭接触者（年龄范围4 - 75岁，平均±标准差32.4±15.8；49名男性）进行了随访，他们是急性散发性戊型肝炎患者的家庭成员。在这86名接触者中，68人（79%）抗戊型肝炎病毒IgG抗体检测呈阴性。4人（4.7%）在首例戊型肝炎病例诊断时抗戊型肝炎病毒IgM抗体呈阳性；其中2名接触者可能与首例病例同时感染了戊型肝炎病毒，另外2名可能发生了家庭内传播。在首例病例诊断后的49±18天内，无人出现戊型肝炎病毒感染的血清学证据，尽管大多数人缺乏抗戊型肝炎病毒IgG抗体，可能易感。这表明散发性戊型肝炎中人际传播并不常见。
