Musk A W, Rouse I L, Rivera B, de Klerk N H, McNulty J C
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Australia.
Br J Ind Med. 1992 Nov;49(11):750-4. doi: 10.1136/oem.49.11.750.
Respiratory symptoms, spirometry, and transfer factor were measured in 208 non-smoking Western Australian underground goldminers (mean age 32) to identify the presence of respiratory abnormalities resulting from underground work. These subjects were part of a larger group of 771 subjects attending for statutory periodic chest x ray examinations in the industry. They had worked underground for a median of three years. The prevalence odds ratios of bronchitis, dyspnoea, wheeze, and asthma all tended to be related to duration of underground employment, even after adjusting for age, those for wheeze and asthma reaching statistical significance. After adjusting for age and height the duration of employment also had a significant effect on TL/VA but not on FEV1, FVC, or TL. These changes are consistent with the presence of airway narrowing and non-specific lung fibrosis or emphysema in non-smoking underground goldminers.
对208名西澳大利亚州非吸烟地下金矿工人（平均年龄32岁）进行了呼吸症状、肺功能测定和肺弥散功能检测，以确定地下工作是否导致呼吸异常。这些受试者是该行业771名参加法定定期胸部X光检查的较大群体的一部分。他们在地下工作的时间中位数为三年。即使在调整年龄后，支气管炎、呼吸困难、喘息和哮喘的患病率比值比均倾向于与地下工作时间相关，喘息和哮喘的患病率比值比具有统计学意义。在调整年龄和身高后，工作时间对肺一氧化碳弥散量/肺泡通气量（TL/VA）也有显著影响，但对第一秒用力呼气容积（FEV1）、用力肺活量（FVC）或肺弥散量（TL）没有影响。这些变化与非吸烟地下金矿工人存在气道狭窄和非特异性肺纤维化或肺气肿一致。
