恶性疟原虫在奎宁治疗期间体内持续两代复制的证据。

Evidence for continued two-brood replication of Plasmodium falciparum in vivo during quinine treatment.

作者信息

Davis T M E, Supanaranond W, Pukrittayakamee S, Silamut K, White N J

机构信息

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Headington, Oxford OX3 9DU, UK.

出版信息

Acta Trop. 2003 Dec;89(1):41-5. doi: 10.1016/j.actatropica.2003.09.002.

DOI:10.1016/j.actatropica.2003.09.002

PMID:14636981

Abstract

To investigate the relationship between fever and parasite clearance in falciparum malaria, we studied 54 adults with Plasmodium falciparum infections who were all treated with quinine. The median oral temperature profile showed peaks at 24 h intervals during the first 3 days. Although there was no equivalent pattern evident in the median parasite clearance curve, we hypothesize that small numbers of two distinct parasite broods continued to develop in antiphase through schizogony despite quinine therapy. These data are consistent with previous reports of two dominant broods in untreated humans and monkeys infected with P. falciparum, and highlight the need for an adequate duration of quinine treatment.

摘要

为了研究恶性疟原虫疟疾中发热与寄生虫清除之间的关系，我们对54名感染恶性疟原虫且均接受奎宁治疗的成年人进行了研究。中位口腔温度曲线在前3天每隔24小时出现峰值。尽管中位寄生虫清除曲线中没有明显的等效模式，但我们推测，尽管进行了奎宁治疗，仍有少量两个不同的寄生虫群体通过裂体生殖以反相持续发育。这些数据与之前关于未治疗的感染恶性疟原虫的人类和猴子中有两个优势群体的报道一致，并强调了奎宁治疗足够疗程的必要性。