阳离子富勒烯衍生物的抗菌和抗增殖活性。
Antibacterial and antiproliferative activity of cationic fullerene derivatives.
作者信息
Mashino Tadahiko, Nishikawa Dai, Takahashi Kyoko, Usui Noriko, Yamori Takao, Seki Masako, Endo Toyoshige, Mochizuki Masataka
机构信息
Kyoritsu College of Pharmacy, Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan.
出版信息
Bioorg Med Chem Lett. 2003 Dec 15;13(24):4395-7. doi: 10.1016/j.bmcl.2003.09.040.
PMID:14643333
Abstract
We examined the antibacterial and antiproliferative activities of alkylated C(60)-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.
摘要
我们研究了烷基化C(60)-双(N,N-二甲基碘化吡咯烷鎓)衍生物的抗菌和抗增殖活性。富勒烯衍生物能有效抑制细菌和癌细胞生长。然而，具有长烷基链的富勒烯衍生物未表现出抗菌活性。
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