van Kuijk F J, Buck P
Department of Chemistry and Biochemistry, Montana State University, Bozeman 59717.
Invest Ophthalmol Vis Sci. 1992 Dec;33(13):3493-6.
The fatty acids in the human retina and the macular region were measured quantitatively (mole percent) by gas chromatography. The major fatty acids of the human retina and macula were palmitic, stearic, oleic, arachidonic, and docosahexaenoic. Surprisingly, there was much less docosahexaenoic acid in the macular region (15.9% of total) than in the peripheral retina (22.3% of total). There was a group of "other fatty acids," not any of the five major fatty acids, that were relatively more abundant in the macula (21.0% of total) than in the peripheral retina (10.7% of total). These results indicate that the human macula has a unique biochemical composition, which differs substantially from the peripheral retina. Establishment of the biochemical composition of the macula may be important for helping recognize possible changes associated with diseases such as age-related macular degeneration.
通过气相色谱法定量测定了人视网膜和黄斑区域中的脂肪酸（摩尔百分比）。人视网膜和黄斑的主要脂肪酸为棕榈酸、硬脂酸、油酸、花生四烯酸和二十二碳六烯酸。令人惊讶的是，黄斑区域中的二十二碳六烯酸（占总量的15.9%）比周边视网膜（占总量的22.3%）少得多。有一组“其他脂肪酸”，不属于五种主要脂肪酸中的任何一种，在黄斑中（占总量的21.0%）比在周边视网膜中（占总量的10.7%）相对更丰富。这些结果表明，人黄斑具有独特的生化组成，与周边视网膜有很大不同。确定黄斑的生化组成可能有助于识别与年龄相关性黄斑变性等疾病相关的可能变化。
