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1
Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals.呼出气一氧化氮水平、血液嗜酸性粒细胞增多与儿童哮喘气道阻塞可逆性之间的相关性仅在特应性个体中可检测到。
Pediatr Pulmonol. 2003 May;35(5):358-63. doi: 10.1002/ppul.10264.
2
Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma.呼出一氧化氮用于哮喘诊断的有效性的前瞻性评估。
Chest. 2003 Mar;123(3):751-6. doi: 10.1378/chest.123.3.751.
3
Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children.学龄儿童呼出一氧化氮、呼吸道症状、肺功能、支气管高反应性和血液嗜酸性粒细胞之间的关系。
Thorax. 2003 Mar;58(3):242-5. doi: 10.1136/thorax.58.3.242.
4
Multiple roles of nitric oxide in the airways.一氧化氮在气道中的多种作用。
Thorax. 2003 Feb;58(2):175-82. doi: 10.1136/thorax.58.2.175.
5
Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate.呼出一氧化氮作为哮喘的诊断测试：在线与离线技术及流速的影响
Am J Respir Crit Care Med. 2002 Jun 15;165(12):1597-601. doi: 10.1164/rccm.2201081.
6
Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms.特应性儿童呼出一氧化氮水平：与特异性过敏致敏、气道高反应性及呼吸道症状的关系。
Thorax. 2002 Jun;57(6):518-23. doi: 10.1136/thorax.57.6.518.
7
Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone.口服泼尼松龙治疗后难治性哮喘患儿呼出一氧化氮与黏膜嗜酸性粒细胞炎症的关系
Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 1):1376-81. doi: 10.1164/ajrccm.164.8.2101145.
8
Exhaled nitric oxide and asthma in young children.幼儿呼出一氧化氮与哮喘
Pediatr Pulmonol. 2001 Oct;32(4):308-13. doi: 10.1002/ppul.1124.
9
Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene.囊性纤维化患者气道中的一氧化氮水平与神经元型一氧化氮合酶基因的多态性有关。
Am J Respir Crit Care Med. 2000 Dec;162(6):2172-6. doi: 10.1164/ajrccm.162.6.2003106.
10
Exhaled nitric oxide in patients with asthma: association with NOS1 genotype.哮喘患者呼出的一氧化氮：与NOS1基因型的关联。
Am J Respir Crit Care Med. 2000 Dec;162(6):2043-7. doi: 10.1164/ajrccm.162.6.2003089.

呼出气一氧化氮与哮喘：儿童社区人群中特应性、气道反应性和症状之间的复杂相互作用。

Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children.

作者信息

Franklin P J, Turner S W, Le Souëf P N, Stick S M

机构信息

Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Australia.

出版信息

Thorax. 2003 Dec;58(12):1048-52. doi: 10.1136/thorax.58.12.1048.

DOI:10.1136/thorax.58.12.1048
PMID:14645971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1746531/
Abstract

BACKGROUND

Exhaled nitric oxide (FE(NO)) is raised in asthmatic children, but there are inconsistencies in the relationship between FE(NO) and characteristics of asthma, including atopy, increased airway responsiveness (AR), and airway inflammation. The aim of this study was to investigate the relationship between FE(NO) and asthma, atopy, and increased AR in children.

METHODS

One hundred and fifty five children (79 boys) of mean age 11.5 years underwent an assessment that included FE(NO) measurements, spirometric tests, inhaled histamine challenge, and a skin prick test. Blood was collected for eosinophil count. Current and past asthma like symptoms were determined by questionnaire.

RESULTS

In multiple linear regression analyses FE(NO) was associated with atopy (p<0.001), level of AR (p = 0.005), blood eosinophil count (p = 0.007), and height (p = 0.002) but not with physician diagnosed asthma (p = 0.1) or reported wheeze in the last 12 months (p = 0.5). Separate regression models were conducted for atopic and non-atopic children and associations between FE(NO) and AR, blood eosinophils and height were only evident in atopic children. Exhaled NO was raised in children with a combination of atopy and increased AR independent of symptoms.

CONCLUSION

Raised FE(NO) seems to be associated with an underlying mechanism linking atopy and AR but not necessarily respiratory symptoms.

摘要

背景

哮喘儿童呼出一氧化氮（FE(NO)）水平升高，但FE(NO)与哮喘特征之间的关系存在不一致，这些特征包括特应性、气道反应性（AR）增加和气道炎症。本研究旨在调查儿童FE(NO)与哮喘、特应性和AR增加之间的关系。

方法

155名平均年龄11.5岁的儿童（79名男孩）接受了一项评估，包括FE(NO)测量、肺功能测试、吸入组胺激发试验和皮肤点刺试验。采集血液进行嗜酸性粒细胞计数。通过问卷调查确定当前和过去的哮喘样症状。

结果

在多元线性回归分析中，FE(NO)与特应性（p<0.001）、AR水平（p = 0.005）、血液嗜酸性粒细胞计数（p = 0.007）和身高（p = 0.002）相关，但与医生诊断的哮喘（p = 0.1）或过去12个月内报告的喘息（p = 0.5）无关。对特应性和非特应性儿童进行了单独的回归模型分析，FE(NO)与AR、血液嗜酸性粒细胞和身高之间的关联仅在特应性儿童中明显。特应性和AR增加并存的儿童呼出一氧化氮升高，与症状无关。

结论

FE(NO)升高似乎与一种潜在机制有关，该机制将特应性和AR联系起来，但不一定与呼吸道症状有关。