基于人群的2型糖尿病患者样本中的餐后甘油三酯情况

Post-prandial triglyceride profile in a population-based sample of Type 2 diabetic patients.

作者信息

Iovine C, Vaccaro O, Gentile A, Romano G, Pisanti F, Riccardi G, Rivellese A A

机构信息

Department of Clinical and Experimental Medicine, Federico II University, Via S. Pansini 5, 80131 Napoli, Italy.

出版信息

Diabetologia. 2004 Jan;47(1):19-22. doi: 10.1007/s00125-003-1269-3. Epub 2003 Nov 26.

DOI:10.1007/s00125-003-1269-3

PMID:14647893

Abstract

AIMS/HYPOTHESIS: Postprandial lipaemia is considered an emerging risk factor for cardiovascular disease also in the Type 2 diabetic population. However, little information exists on the daily triglyceride profile of these patients, especially during everyday life. The aim of the study was to evaluate the daily triglyceride profile of Type 2 diabetic patients during their everyday life.

METHODS

145 Type 2 diabetic patients (66 men/79 women, age range 45-65 years) at a health district near Naples, Italy, participating in a screening survey for the evaluation of diabetic complications, and 30 non-diabetic subjects of the same area underwent four daily capillary triglyceride profiles by Accutrend (Roche)-a previously validated method.

RESULTS

Triglyceride values (mmol/l; Means +/- SE) were 2.22+/-0.08 at fasting, decreased before lunch (2.03+/-0.07), reached a peak 3 h after lunch (2.73+/-0.09) and remained substantially high before dinner (2.47+/-0.09) (all p<0.001 vs fasting). The triglyceride profile of non-diabetic subjects was significantly lower at each point (average difference of 0.73 mmol/l). The percentage of patients with values above 2.25 mmol/l was 61% 3 h after lunch and 49% before dinner. Moreover, in 30% of patients with optimal fasting values (<1.69 mmol/l) triglyceride concentrations 3 h after lunch ranged between 1.69 and 2.25 mmol/l, and in 31% they were above 2.25 mmol/l.

CONCLUSION/INTERPRETATION: Most Type 2 diabetic patients have postprandial triglycerides above optimal concentrations for several hours after meals. Moreover, optimal fasting concentrations are not always a good predictor of postprandial triglycerides.

摘要

目的/假设：餐后血脂异常被认为是2型糖尿病患者心血管疾病的一个新出现的危险因素。然而，关于这些患者的日常甘油三酯情况，尤其是在日常生活中的情况，了解甚少。本研究的目的是评估2型糖尿病患者在日常生活中的日常甘油三酯情况。

方法

在意大利那不勒斯附近一个健康区，145名2型糖尿病患者（66名男性/79名女性，年龄范围45 - 65岁）参与了一项糖尿病并发症评估筛查调查，同一地区的30名非糖尿病受试者通过Accutrend（罗氏）进行了四次每日毛细血管甘油三酯检测——这是一种先前已验证的方法。

结果

空腹时甘油三酯值（mmol/L；均值±标准误）为2.22±0.08，午餐前下降（2.03±0.07），午餐后3小时达到峰值（2.73±0.09），晚餐前仍显著升高（2.47±0.09）（与空腹相比，所有p<0.001）。非糖尿病受试者的甘油三酯情况在各时间点均显著更低（平均差异为0.73 mmol/L）。午餐后3小时甘油三酯值高于2.25 mmol/L的患者百分比为61%，晚餐前为49%。此外，在空腹值最佳（<1.69 mmol/L）的患者中，30%的患者午餐后3小时甘油三酯浓度在1.69至2.25 mmol/L之间，31%的患者高于2.25 mmol/L。

结论/解读：大多数2型糖尿病患者餐后甘油三酯在餐后数小时内高于最佳浓度。此外，空腹时的最佳浓度并不总是餐后甘油三酯的良好预测指标。