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妊娠晚期感染水痘的风险。

Risk of varicella infection during late pregnancy.

作者信息

Koren Gideon

机构信息

Motherisk Team, Hospital for Sick Children in Toronto, Ont.

出版信息

Can Fam Physician. 2003 Nov;49:1445-6.

PMID:14649980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2214156/
Abstract

QUESTION

I have a patient who contracted varicella at 26 weeks' gestation. She is very concerned and would consider termination if it were earlier in the pregnancy. What are the current predictions of risk for her fetus?

ANSWER

Based on review of all available studies, we could not detect a single case of congenital varicella syndrome in the third trimester of pregnancy (0/208), as compared with 5/645 (0.78%) in the first and 9/592 (1.52%) in the second trimester (P < .01 third vs first and second). You can reassure your patient.

摘要

问题

我有一位患者，在妊娠26周时感染了水痘。她非常担心，如果妊娠时间再早一些，她会考虑终止妊娠。目前对她胎儿的风险预测是什么？

答案

基于对所有现有研究的回顾，我们在妊娠晚期未发现一例先天性水痘综合征（0/208），而在妊娠早期为5/645（0.78%），妊娠中期为9/592（1.52%）（晚期与早期和中期相比，P <.01）。你可以让你的患者放心。

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1
Risk of varicella infection during late pregnancy.妊娠晚期感染水痘的风险。
Can Fam Physician. 2003 Nov;49:1445-6.
2
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3
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Am J Perinatol. 2000;17(5):253-6. doi: 10.1055/s-2000-10007.
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5
[Varicella during pregnancy: consequences for the mother and the newborn].[孕期水痘：对母亲和新生儿的影响]
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Varicella-zoster contracted in the second trimester of pregnancy.孕期第二个月感染水痘带状疱疹病毒。
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Epidemiology and factors influencing varicella infections in tropical countries including Sri Lanka.包括斯里兰卡在内的热带国家水痘感染的流行病学及影响因素。
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本文引用的文献

1
Varicella vaccine: rare serious problems--but the benefits still outweigh the risks.水痘疫苗：罕见的严重问题——但益处仍大于风险。
J Infect Dis. 2003 Oct 1;188(7):945-7. doi: 10.1086/378504. Epub 2003 Sep 26.
2
Virus diseases in pregnancy and congenital defects.孕期病毒疾病与先天性缺陷
Br J Prev Soc Med. 1958 Jan;12(1):1-7. doi: 10.1136/jech.12.1.1.
3
Frequency of congenital varicella syndrome in a prospective cohort of 347 pregnant women.347名孕妇前瞻性队列中先天性水痘综合征的发生率
Obstet Gynecol. 2002 Aug;100(2):260-5. doi: 10.1016/s0029-7844(02)02059-8.
4
Serum concentrations, efficacy, and safety of a new, intravenously administered varicella zoster immune globulin in pregnant women.一种新型静脉注射水痘带状疱疹免疫球蛋白在孕妇中的血清浓度、疗效及安全性
J Clin Pharmacol. 2002 Mar;42(3):267-74. doi: 10.1177/00912700222011283.
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Serum tumor necrosis factor-alpha in neonatal sepsis.
Am J Perinatol. 1997 Aug;14(7):401-4. doi: 10.1055/s-2007-994168.
6
Offspring of women infected with varicella during pregnancy: a prospective study.孕期感染水痘的女性所生子女：一项前瞻性研究。
Teratology. 1994 Jan;49(1):29-32. doi: 10.1002/tera.1420490106.
7
Outcome after maternal varicella infection in the first 20 weeks of pregnancy.妊娠前20周孕妇感染水痘后的结局。
N Engl J Med. 1994 Mar 31;330(13):901-5. doi: 10.1056/NEJM199403313301305.
8
Consequences of varicella and herpes zoster in pregnancy: prospective study of 1739 cases.妊娠期水痘和带状疱疹的后果：1739例病例的前瞻性研究
Lancet. 1994 Jun 18;343(8912):1548-51. doi: 10.1016/s0140-6736(94)92943-2.
9
Congenital malformations following chickenpox, measles, mumps, and hepatitis. Results of a cohort study.水痘、麻疹、腮腺炎及肝炎后的先天性畸形。一项队列研究的结果。
JAMA. 1973 Dec 24;226(13):1521-4.
10
Fetal varicella syndrome.
J Pediatr. 1987 Sep;111(3):320-3. doi: 10.1016/s0022-3476(87)80447-x.