Chim S S C, Tsui S K W, Chan K C A, Au T C C, Hung E C W, Tong Y K, Chiu R W K, Ng E K O, Chan P K S, Chu C M, Sung J J Y, Tam J S, Fung K P, Waye M M Y, Lee C Y, Yuen K Y, Lo Y M D
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Lancet. 2003 Nov 29;362(9398):1807-8. doi: 10.1016/s0140-6736(03)14901-x.
Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
严重急性呼吸综合征(SARS)是一个全球关注的健康问题。在香港,确认了两次主要疫情爆发,一次发生在医院,另一次发生在淘大花园公寓。两次疫情中腹泻、入住重症监护病房的频率以及死亡率存在显著差异。我们对来自淘大花园五名患者的病毒分离株进行了基因组测序。这五名患者中有四名的病毒序列相同。一名医院病例和四名相同社区病例的序列数据仅有三个核苷酸差异。严重急性呼吸综合征冠状病毒基因组的改变不太可能导致淘大花园患者独特的临床特征,这些结果凸显了非病毒基因组因素在此次疫情中的重要性。