Riezman Howard
Department of Biochemistry, Sciences II, 30 quai E. Ansermet, CH-1211 Geneva 4, Switzerland.
Cell Cycle. 2004 Jan;3(1):61-3.
The cellular response to heat stress includes the induction of a group of proteins called the Heat Shock Proteins, whose functions include the synthesis of the thermoprotectant trehalose, refolding of denatured proteins, and ubiquitin- and proteasome-dependent degradation. Recent studies show that simply increasing the activity of ubiquitin- and proteasome-dependent degradation can replace the essential functions played by the induction of heat shock proteins during a heat stress. These results suggest that accumulation of denatured or aggregated proteins is the reason for the loss of cell viability due to heat stress.
细胞对热应激的反应包括诱导产生一组名为热休克蛋白的蛋白质，其功能包括合成热保护剂海藻糖、使变性蛋白质重新折叠，以及泛素和蛋白酶体依赖性降解。最近的研究表明，简单地提高泛素和蛋白酶体依赖性降解的活性，就可以替代热应激期间热休克蛋白诱导所发挥的基本功能。这些结果表明，变性或聚集蛋白质的积累是热应激导致细胞活力丧失的原因。
