粗糙脉孢菌中异丙基苹果酸异构酶合成的调控
Regulation of isopropylmalate isomerase synthesis in Neurospora crassa.
作者信息
Reichenbecher V E, Fischer M, Gross S R
出版信息
J Bacteriol. 1978 Feb;133(2):794-801. doi: 10.1128/jb.133.2.794-801.1978.
Abstract
The capacity to synthetize isopropylmalate isomerase (EC 4.2.1.33) by Neurospora crassa increased during induction in the presence of cycloheximide but was inhibited by proflavine and other inhibitors of RNA synthesis. Turnover of the enzyme once formed appeared negligible, but the message (measured as enzyme-forming capacity) had a half-life of 4 to 8 min. A comparison of the kinetics of induction in the wild type and a newly isolated alpha-isopropylmalate-permeable strain suggested strongly that feedback control by leucine of alpha-isopropylmalate production can adequately serve as the primary physiological regulator of endogenous inducer concentration. Genetic data are presented which implicate the involvement of two unlinked genes, ipm-1 and ipm-2, in determining permeation of alpha-isopropylmalate.
摘要
粗糙脉孢菌合成异丙基苹果酸异构酶（EC 4.2.1.33）的能力在环己酰亚胺存在下诱导过程中增加，但受到原黄素和其他RNA合成抑制剂的抑制。一旦形成，该酶的周转似乎可以忽略不计，但信息（以酶形成能力衡量）的半衰期为4至8分钟。对野生型和新分离的α-异丙基苹果酸通透菌株诱导动力学的比较强烈表明，亮氨酸对α-异丙基苹果酸产生的反馈控制可以充分作为内源性诱导剂浓度的主要生理调节剂。给出的遗传数据表明，两个不连锁的基因ipm-1和ipm-2参与了α-异丙基苹果酸通透的决定。
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