Ryu Ji-Hwan, Nam Ki-Bum, Oh Chun-Taek, Nam Hyuck-Jin, Kim Sung-Hee, Yoon Joo-Heon, Seong Je-Kyeong, Yoo Mi-Ae, Jang In-Hwan, Brey Paul T, Lee Won-Jae
Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Womans University, Seoul, South Korea.
Mol Cell Biol. 2004 Jan;24(1):172-85. doi: 10.1128/MCB.24.1.172-185.2004.
In Drosophila melanogaster, although the NF-kappaB transcription factors play a pivotal role in the inducible expression of innate immune genes, such as antimicrobial peptide genes, the exact regulatory mechanism of the tissue-specific constitutive expression of these genes in barrier epithelia is largely unknown. Here, we show that the Drosophila homeobox gene product Caudal functions as the innate immune transcription modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner. These results suggest that certain epithelial tissues have evolved a unique constitutive innate immune strategy by recruiting a developmental "master control" gene.
在黑腹果蝇中，尽管核因子-κB转录因子在先天免疫基因（如抗菌肽基因）的诱导性表达中起关键作用，但这些基因在屏障上皮组织中组织特异性组成性表达的确切调控机制仍 largely unknown。在这里，我们表明果蝇同源框基因产物尾端蛋白作为先天免疫转录调节因子，以组织特异性方式负责抗菌肽天蚕素和果蝇霉素的组成性局部表达。这些结果表明，某些上皮组织通过招募一个发育“主控”基因，进化出了一种独特的组成性先天免疫策略。
