Wolvetang E J, Bradfield O M, Hatzistavrou T, Crack P J, Busciglio J, Kola I, Hertzog P J
Monash Institute of Reproduction and Development, Monash University, Monash Medical Center, 246 Clayton Road, 3168 Clayton, Australia.
Neurobiol Dis. 2003 Dec;14(3):349-56. doi: 10.1016/s0969-9961(03)00107-4.
Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in neurons, and that moderate overexpression of Ets2 leads to increased apoptosis of primary neuronal cultures from Ets2 tg mice that involves activation of caspase-3. Our data therefore suggest that overexpression of ETS2 may contribute to the increased rate of apoptosis of neurons in Down syndrome.
唐氏综合征（21三体综合征）患者的神经元在体外显示出凋亡率增加。21号染色体上介导这种细胞死亡增加的基因仍有待阐明。在此我们表明，21号染色体转录因子Ets2（一种在唐氏综合征中过表达的基因）在神经元中表达，并且Ets2的适度过表达会导致来自Ets2转基因小鼠的原代神经元培养物凋亡增加，这涉及半胱天冬酶-3的激活。因此，我们的数据表明ETS2的过表达可能导致唐氏综合征患者神经元凋亡率增加。
