Cunha B A
Winthrop-University Hospital, Mineola, New York.
Clin Ther. 1992 Sep-Oct;14(5):616-52; discussion 615.
Third-generation cephalosporins play a pivotal role in the management of infections because of their potent and broad-spectrum antimicrobial activity, proven clinical efficacy in a wide variety of infections, safety, and potential for cost savings. Selection of third-generation cephalosporins poses a dilemma, however, particularly for clinicians who view the six antibiotics within this class as interchangeable. Choice of drug should be based on antimicrobial spectrum and other factors such as lack of resistance development and cost considerations. This review focuses on the distinguishing features of the parenteral third-generation cephalosporins. Such differences suggest the need for retiring the convenient "generation" classification system for cephalosporins in favor of a system that encourages recognition of clinically important features of each agent in this diverse group of cephalosporin antibiotics.
第三代头孢菌素因其强大的广谱抗菌活性、在多种感染中已证实的临床疗效、安全性以及潜在的成本节约，在感染管理中发挥着关键作用。然而，第三代头孢菌素的选择带来了一个难题，特别是对于那些认为该类中的六种抗生素可相互替代的临床医生而言。药物的选择应基于抗菌谱以及其他因素，如耐药性发展情况和成本考量。本综述聚焦于胃肠外第三代头孢菌素的显著特征。这些差异表明，有必要摒弃方便但并不科学的头孢菌素“代”分类系统，转而采用一种鼓励认识这一多样的头孢菌素抗生素组中每种药物临床重要特征的系统。
