Kulkarni-Kale Urmila, Bhosle Shriram, Manjari G Sunitha, Kolaskar A S
Bioinformatics Centre, University of Pune, Pune 411 007, India.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D289-92. doi: 10.1093/nar/gkh098.
VirGen is a comprehensive viral genome resource that organizes the 'sequence space' of viral genomes in a structured fashion. It has been developed with the objective of serving as an annotated and curated database comprising complete genome sequences of viruses, value-added derived data and data mining tools. The current release (v1.1) contains 559 complete genomes in addition to 287 putative genomes of viruses belonging to eight viral families for which the host range includes animals and plants. Viral genomes in VirGen are annotated using sequence-based Bioinformatics approaches. The genomic data is also curated to identify 'alternate names' of viral proteins, where available. VirGen archives the results of comparisons of genomes, proteomes and individual proteins within and between viral species. It is the first resource to provide phylogenetic trees of viral species computed using whole-genome sequence data. The module of predicted B-cell antigenic determinants in VirGen is an attempt to link the genome to its vaccinome. Comparative genome analysis data facilitate the study of genome organization and evolution of viruses, which would have implications in applied research to identify candidates for the design of vaccines and antiviral drugs. VirGen is a relational database and is available at http://bioinfo. ernet.in/virgen/virgen.html.
VirGen是一个全面的病毒基因组资源库，它以结构化的方式组织病毒基因组的“序列空间”。其开发目的是作为一个包含病毒完整基因组序列、增值衍生数据和数据挖掘工具的注释和整理数据库。当前版本（v1.1）除了包含属于八个病毒科的287个推测病毒基因组外，还包含559个完整基因组，这些病毒的宿主范围包括动物和植物。VirGen中的病毒基因组使用基于序列的生物信息学方法进行注释。基因组数据也经过整理以识别病毒蛋白的“别名”（如果有的话）。VirGen存档了病毒物种内部和之间基因组、蛋白质组和单个蛋白质的比较结果。它是第一个提供使用全基因组序列数据计算的病毒物种系统发育树的资源库。VirGen中预测的B细胞抗原决定簇模块试图将基因组与其疫苗组联系起来。比较基因组分析数据有助于研究病毒的基因组组织和进化，这将对应用研究产生影响，以确定疫苗和抗病毒药物设计的候选对象。VirGen是一个关系数据库，可在http://bioinfo.ernet.in/virgen/virgen.html上获取。
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