迈向海兔毒素A的全合成：C8 - C19区域的对映选择性制备
Toward a total synthesis of peloruside A: enantioselective preparation of the C8-C19 region.
作者信息
Taylor Richard E, Jin Meizhong
机构信息
Department of Chemistry and Biochemistry and the Walther Cancer Research Center, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556-5670, USA.
出版信息
Org Lett. 2003 Dec 25;5(26):4959-61. doi: 10.1021/ol0358814.
PMID:14682739
Abstract
An efficient synthetic sequence toward the C8-C19 region of peloruside A has been developed. The route is highlighted by a selective electrophilic cyclization reaction, a single-step epoxide ring-opening/methylation sequence, and a stereoselective Mukaiyama aldol reaction. [reaction: see text]
摘要
已开发出一种高效合成海兔毒素A中C8 - C19区域的序列。该路线的亮点在于选择性亲电环化反应、一步环氧化合物开环/甲基化序列以及立体选择性的 Mukaiyama 羟醛反应。[反应：见正文]
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