Marrie T J, Cunning J, Durnford P
Department of Medicine, Dalhousi University, Nova Scotia, Canada.
Eur J Clin Microbiol Infect Dis. 1992 Sep;11(9):833-6. doi: 10.1007/BF01960885.
To determine whether reactivation of Q fever occurs following cardiac surgery 43 patients who had antibodies to Coxiella burnetii were identified pre-operatively. Serum samples were collected 1, 4 to 6, and 24 weeks post-operatively. One patient had active Q fever endocarditis. Seven of the remaining 42 (17%) had a > or = fourfold rise in titres for antibodies to Coxiella burnetii post-operatively. Only two of these seven had an increase in antibody titres for other agents suggesting that the fourfold titre rise for Coxiella burnetii was not part of a polyclonal response. It is concluded that self-limited reactivation of infection may occur among Coxiella burnetii seropositive patients undergoing open heart surgery.
为确定心脏手术后是否会发生Q热再激活，术前识别出43例对伯纳特立克次体有抗体的患者。术后1周、4至6周和24周采集血清样本。1例患者患有活动性Q热心内膜炎。其余42例中的7例（17%）术后针对伯纳特立克次体的抗体滴度有≥四倍的升高。这7例中只有2例其他病原体的抗体滴度增加，提示伯纳特立克次体四倍滴度升高并非多克隆反应的一部分。得出的结论是，接受心脏直视手术的伯纳特立克次体血清阳性患者可能会发生感染的自限性再激活。
