Thalheimer U, Mela M, Patch D, Burroughs A K
Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, Pond St, London NW3 2QG, UK.
Gut. 2004 Jan;53(1):143-8. doi: 10.1136/gut.53.1.143.
Recurrent variceal bleeding is very frequent after variceal haemorrhage and pharmacological therapy is the first choice treatment. Recently, baseline and repeat measurements of hepatic venous pressure gradient (HVPG) have been considered necessary to optimally manage patients receiving pharmacological therapy so as to reduce the frequency of rebleeding. However, the clinical validity and applicability of monitoring for target HVPG reductions is not sufficiently proven and needs to be specifically evaluated in a prospective trial.
静脉曲张出血后复发性静脉曲张出血非常常见,药物治疗是首选治疗方法。最近,肝静脉压力梯度(HVPG)的基线测量和重复测量被认为对于优化接受药物治疗的患者管理至关重要,以便降低再出血频率。然而,监测目标HVPG降低的临床有效性和适用性尚未得到充分证实,需要在前瞻性试验中进行具体评估。