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门静脉高压症药物治疗期间监测肝静脉压力梯度的目标降低：审视证据

Monitoring target reduction in hepatic venous pressure gradient during pharmacological therapy of portal hypertension: a close look at the evidence.

作者信息

Thalheimer U, Mela M, Patch D, Burroughs A K

机构信息

Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, Pond St, London NW3 2QG, UK.

出版信息

Gut. 2004 Jan;53(1):143-8. doi: 10.1136/gut.53.1.143.

DOI:10.1136/gut.53.1.143
PMID:14684589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1773917/
Abstract

Recurrent variceal bleeding is very frequent after variceal haemorrhage and pharmacological therapy is the first choice treatment. Recently, baseline and repeat measurements of hepatic venous pressure gradient (HVPG) have been considered necessary to optimally manage patients receiving pharmacological therapy so as to reduce the frequency of rebleeding. However, the clinical validity and applicability of monitoring for target HVPG reductions is not sufficiently proven and needs to be specifically evaluated in a prospective trial.

摘要

静脉曲张出血后复发性静脉曲张出血非常常见，药物治疗是首选治疗方法。最近，肝静脉压力梯度（HVPG）的基线测量和重复测量被认为对于优化接受药物治疗的患者管理至关重要，以便降低再出血频率。然而，监测目标HVPG降低的临床有效性和适用性尚未得到充分证实，需要在前瞻性试验中进行具体评估。

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本文引用的文献

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Spontaneous decrease in portal pressure with clinical improvement in cirrhosis.肝硬化患者门静脉压力随临床改善而自发降低。
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Prevention of variceal rebleeding.预防静脉曲张再出血。
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Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis.门静脉高压症药物治疗的血流动力学反应及肝硬化的长期预后
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Prevention of variceal rebleeding.预防静脉曲张再出血。
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Hepatic venous pressure gradient measurements to assess response to primary prophylaxis in patients with cirrhosis: a decision analytical study.肝静脉压力梯度测量用于评估肝硬化患者一级预防的反应：一项决策分析研究。
Aliment Pharmacol Ther. 2003 Jan;17(1):145-53. doi: 10.1046/j.1365-2036.2003.01391.x.
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A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis.一项关于药物治疗与内镜下结扎术预防肝硬化患者静脉曲张再出血的随机对照试验。
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