Belliveau J W, Kwong K K, Kennedy D N, Baker J R, Stern C E, Benson R, Chesler D A, Weisskoff R M, Cohen M S, Tootell R B
MGH-NMR Center, Boston, Massachusetts.
Invest Radiol. 1992 Dec;27 Suppl 2(0 2):S59-65. doi: 10.1097/00004424-199212002-00011.
Magnetic resonance imaging (MRI) studies of human brain activity are described. Task-induced changes in brain cognitive state were measured using high-speed MRI techniques sensitive to changes in cerebral blood volume (CBV), blood flow (CBF), and blood oxygenation. These techniques were used to generate the first functional MRI maps of human task activation, by using a visual stimulus paradigm. The methodology of MRI brain mapping and results from the investigation of the functional organization and frequency response of human primary visual cortex (V1) are presented.
本文描述了对人类大脑活动的磁共振成像（MRI）研究。使用对脑血容量（CBV）、血流（CBF）和血液氧合变化敏感的高速MRI技术，测量了任务诱导的大脑认知状态变化。通过视觉刺激范式，这些技术被用于生成人类任务激活的首张功能MRI图谱。本文介绍了MRI脑图谱绘制方法以及对人类初级视觉皮层（V1）功能组织和频率响应研究的结果。
