Thulborn K R, Waterton J C, Matthews P M, Radda G K
Biochim Biophys Acta. 1982 Feb 2;714(2):265-70. doi: 10.1016/0304-4165(82)90333-6.
At high and medium magnetic field, the transverse NMR relaxation rate (T-1(2)) of water proteins in blood is determined predominantly by the oxygenation state of haemoglobin. T-1(2) depends quadratically on the field strength and on the proportion of haemoglobin that is deoxygenated. Deoxygenation increases the volume magnetic susceptibility within the erythrocytes and thus creates local field gradients around these cells. From volume susceptibility measurements and the dependence of T-1(2) on the pulse rate in the Carr-Purcell-Meiboom-Gill experiment, we show that the increase in T-1(2) with increasing blood deoxygenation arises from diffusion of water through these field gradients.
在中高磁场下，血液中水分子与蛋白质的横向核磁共振弛豫率（T-1(2)）主要由血红蛋白的氧合状态决定。T-1(2)与场强以及脱氧血红蛋白的比例呈二次方关系。脱氧作用会增加红细胞内的体积磁化率，从而在这些细胞周围产生局部场梯度。通过体积磁化率测量以及在Carr-Purcell-Meiboom-Gill实验中T-1(2)对脉冲速率的依赖性，我们表明随着血液脱氧程度增加，T-1(2)升高是由于水通过这些场梯度扩散所致。
