通过ATP依赖的染色质重塑活性进行组蛋白H2A/H2B二聚体交换。
Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities.
作者信息
Bruno Michael, Flaus Andrew, Stockdale Chris, Rencurel Chantal, Ferreira Helder, Owen-Hughes Tom
机构信息
Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
出版信息
Mol Cell. 2003 Dec;12(6):1599-606. doi: 10.1016/s1097-2765(03)00499-4.
Abstract
ATP-dependent chromatin remodeling activities function to manipulate chromatin structure during gene regulation. One of the ways in which they do this is by altering the positions of nucleosomes along DNA. Here we provide support for the ability of these complexes to move nucleosomes into positions in which DNA is unraveled from one edge. This is expected to result in the loss of histone-DNA contacts that are important for retention of one H2A/H2B dimer within the nucleosome. Consistent with this we find that several chromatin remodeling complexes are capable of catalyzing the exchange of H2A/H2B dimers between chromatin fragments in an ATP-dependent reaction. This provides eukaryotes with additional means by which they may manipulate chromatin structure.
摘要
ATP 依赖的染色质重塑活性在基因调控过程中发挥作用，以操纵染色质结构。它们实现这一目的的一种方式是改变核小体沿 DNA 的位置。在这里，我们为这些复合物将核小体移动到 DNA 从一条边缘解开的位置的能力提供了支持。这预计会导致对一个 H2A/H2B 二聚体保留在核小体内很重要的组蛋白 - DNA 接触的丧失。与此一致，我们发现几种染色质重塑复合物能够在依赖 ATP 的反应中催化染色质片段之间 H2A/H2B 二聚体的交换。这为真核生物提供了额外的操纵染色质结构的手段。
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