组蛋白伴侣、组蛋白乙酰化和染色质基因组的流动性。
Histone chaperones, histone acetylation, and the fluidity of the chromogenome.
机构信息
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
J Cell Physiol. 2010 Aug;224(2):289-99. doi: 10.1002/jcp.22150.
Abstract
The "chromogenome" is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function.
摘要
“色质体”被定义为真核细胞内基因组在任何特定时刻的结构和功能状态。本文主要关注组蛋白伴侣、组蛋白翻译后乙酰化以及色质体调节之间新发现的关系。我们强调那些以与复制无关的方式发挥作用的伴侣，并且已经获得了它们的三维结构信息。讨论了在酵母和高等后生动物中组蛋白乙酰化与伴侣功能之间新出现的联系，包括无核小体区域的重要性。最后，我们提出了许多关于组蛋白伴侣和乙酰化的偶联作用如何影响色质体结构和功能的问题。
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