Fleming Shelley K, Blasey Christine, Schatzberg Alan F
Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, CA 94305, USA.
J Psychiatr Res. 2004 Jan;38(1):27-35. doi: 10.1016/s0022-3956(03)00100-6.
Neuropsychological functioning has been a focus of study in psychotic disorders for many decades. These studies have focused primarily on schizophrenia, and less so on the affective psychoses, including psychotic major depression PMD. Several studies have provided evidence of cognitive dysfunction in PMD. However, these studies have utilized different assessment methods and instruments. Consequently, a clear picture of the nature and severity of cognitive impairment in PMD has yet to emerge in the literature. The current review seeks to provide a summary of the literature by composing a quantitative and qualitative review of the research to date on the cognitive impairment in psychotic major depression, specifically as it contrasts to those deficits observed in nonpsychotic depression. This review also provides a summary model of the pathophysiology of PMD to provide the necessary context to understanding the biological mechanisms of these impairments.
几十年来，神经心理功能一直是精神障碍研究的重点。这些研究主要集中在精神分裂症上，而对情感性精神病，包括伴有精神病性症状的重度抑郁症（PMD）的关注较少。多项研究已提供证据表明PMD存在认知功能障碍。然而，这些研究采用了不同的评估方法和工具。因此，关于PMD认知障碍的性质和严重程度，目前文献中尚未形成清晰的图景。本综述旨在通过对迄今为止有关伴有精神病性症状的重度抑郁症认知障碍的研究进行定量和定性综述，来总结相关文献，特别是将其与非精神病性抑郁症中观察到的缺陷进行对比。本综述还提供了一个PMD病理生理学的总结模型，以提供理解这些障碍生物学机制所需的背景信息。
