Baraczka K, Nékám K, Pozsonyi T, Szüts I, Ormos G
Department of Neuroimmunology, National Institute of Psychiatry and Neurology, Budapest, Hungary.
Eur J Neurol. 2004 Jan;11(1):37-42. doi: 10.1046/j.1351-5101.2003.00706.x.
Humoral immune response seems to play a role in the pathogenesis of multiple sclerosis (MS) and in the central nervous system (CNS) complications of systemic lupus erythematosus (SLE). The aim of the present study was to compare the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-10 in the cerebrospinal fluid of female patients with several forms of MS (50 patients), and in female patients with several types of CNS complications in SLE (50 patients). Samples were investigated using an enzyme-linked immunosorbent assay technique. Involvement of CNS in SLE patients seems to be characterized with elevated concentrations of all three cytokines in CNS and intrathecal synthesis of IL-6. In MS patients, an intrathecal synthesis of TNF-alpha (relapsing-remitting form) and IL-6 (primary progressive form) were observed. Clinical forms of MS seem to be immunologically heterogeneous. The activation of cytokine network was observed in SLE patients with CNS complications, independent of the pathological process. Similarities between SLE and MS patients with the primary progressive form of the disease were demonstrated concerning the intrathecal synthesis of IL-6. Only MS patients with the relapsing-remitting clinical form showed intrathecal TNF-alpha synthesis.
体液免疫反应似乎在多发性硬化症（MS）的发病机制以及系统性红斑狼疮（SLE）的中枢神经系统（CNS）并发症中发挥作用。本研究的目的是比较患有几种形式MS的女性患者（50例）和患有SLE几种类型CNS并发症的女性患者（50例）脑脊液中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和IL-10的水平。使用酶联免疫吸附测定技术对样本进行研究。SLE患者中枢神经系统受累似乎表现为中枢神经系统中所有三种细胞因子浓度升高以及IL-6的鞘内合成。在MS患者中，观察到TNF-α（复发缓解型）和IL-6（原发进展型）的鞘内合成。MS的临床形式似乎在免疫方面具有异质性。在患有中枢神经系统并发症的SLE患者中观察到细胞因子网络的激活，与病理过程无关。在疾病的原发进展型方面，SLE和MS患者在IL-6的鞘内合成上表现出相似性。只有复发缓解临床型的MS患者表现出鞘内TNF-α合成。
