Jara L J, Irigoyen L, Ortiz M J, Zazueta B, Bravo G, Espinoza L R
Rheumatology Department, Hospital de Especialidades y Hospital de Gineco-Obstetricia No. 3, C.M. La Raza IMSS, Mexico City, Mexico.
Clin Rheumatol. 1998;17(2):110-4. doi: 10.1007/BF01452255.
We investigated the levels of prolactin (PRL) and interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) and serum of systemic lupus erythematosus patients with central nervous system involvement (CNS-SLE), and examined whether PRL and IL-6 have a relationship. Serum and CSF PRL and IL-6 were measured in the following groups of patients and controls: group I: seven patients with CNS-SLE; group II: three SLE patients without CNS involvement (non CNS-SLE); group III: 10 patients with neurocysticercosis; and group IV: six healthy women. The patients were clinically assessed. CSF PRL and IL-6 were elevated in group I (CNS-SLE) in comparison with all other groups (p<0.001). In addition, four of seven patients had higher levels of IL-6 and PRL in CSF than in serum. A positive correlation between PRL and IL-6 in CSF of SLE was observed (r=0.88, p<0.001). The mean serum PRL concentrations were not significantly different in all groups, but high levels of IL-6 were found in the serum of group I in comparison with groups II and IV (p<0.001). The serum levels of group III were not different from those of group I. These results demonstrate the presence of intrathecal synthesis and elevations of CSF PRL and IL-6 in active CNS-SLE involvement and indicate that measurements of CSF PRL and IL-6 may be useful in the evaluation of neuropsychiatric lupus erythematosus.
我们研究了中枢神经系统受累的系统性红斑狼疮患者（CNS-SLE）脑脊液（CSF）和血清中催乳素（PRL）及白细胞介素-6（IL-6）的水平，并检测PRL和IL-6是否存在关联。对以下几组患者及对照组测定血清和脑脊液中的PRL及IL-6：第一组：7例CNS-SLE患者；第二组：3例无中枢神经系统受累的SLE患者（非CNS-SLE）；第三组：10例神经囊尾蚴病患者；第四组：6名健康女性。对患者进行了临床评估。与所有其他组相比，第一组（CNS-SLE）的脑脊液PRL和IL-6升高（p<0.001）。此外，7例患者中有4例脑脊液中IL-6和PRL水平高于血清。观察到SLE患者脑脊液中PRL与IL-6呈正相关（r=0.88，p<0.001）。所有组的血清PRL平均浓度无显著差异，但与第二组和第四组相比，第一组血清中IL-6水平较高（p<0.001）。第三组的血清水平与第一组无差异。这些结果表明，在活动性CNS-SLE受累中存在脑脊液PRL和IL-6的鞘内合成及升高，提示脑脊液PRL和IL-6的检测可能有助于神经精神性红斑狼疮的评估。
