Rodriguez Teresa, Altieri Andrea, Chatenoud Liliane, Gallus Silvano, Bosetti Cristina, Negri Eva, Franceschi Silvia, Levi Fabio, Talamini Renato, La Vecchia Carlo
Universidad Pùblica de Navarra, Departamento de Ciencias de la Salud, Av. Barañain s/n, 31008 Pamplona, Spain.
Oral Oncol. 2004 Feb;40(2):207-13. doi: 10.1016/j.oraloncology.2003.08.014.
Mortality from oral cancer has been rising in the young in several areas of the world until the early 1990s. We analysed data from two case-control studies from Italy and Switzerland including 137 cases of oral and pharyngeal cancer below age 46 and 298 hospital controls. The multivariate odds ratios (OR) were 20.7 for heavy smokers and 4.9 for heavy drinkers. The combination of high tobacco and alcohol consumption led to an OR of over 48. Body mass index (OR=0.28, for the highest tertile), high consumption of coffee (OR=0.25), fresh vegetables (OR=0.39), fruit (OR=0.73) and beta-carotene (OR=0.48) were inversely related to risk. Tobacco accounted for 77% of all cancer cases in this population, alcohol for 52%, low vegetable consumption for 52%, and the combination of the three factors for 85%.
直到20世纪90年代初，世界上几个地区年轻人的口腔癌死亡率一直在上升。我们分析了来自意大利和瑞士的两项病例对照研究的数据，其中包括137例46岁以下的口腔和咽癌病例以及298名医院对照者。重度吸烟者的多变量优势比（OR）为20.7，重度饮酒者为4.9。高烟草和酒精消费的组合导致OR超过48。体重指数（最高三分位数的OR = 0.28）、高咖啡消费量（OR = 0.25）、新鲜蔬菜（OR = 0.39）、水果（OR = 0.73）和β-胡萝卜素（OR = 0.48）与风险呈负相关。在该人群中，烟草导致了所有癌症病例的77%，酒精导致52%，低蔬菜消费量导致52%，这三个因素的组合导致85%。
