Tavani A, Gallus S, La Vecchia C, Talamini R, Barbone F, Herrero R, Franceschi S
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Eur J Cancer Prev. 2001 Apr;10(2):191-5. doi: 10.1097/00008469-200104000-00015.
The relation between diet and risk of oral and pharyngeal cancer was analysed in a case-control study conducted in North-East Italy between 1996 and 1999. Cases were 132 patients (including 33 women), with incident, histologically confirmed cancer of the oral cavity or pharynx, and controls were 148 subjects (including 45 women) admitted to hospitals for acute conditions unrelated to smoking or alcohol drinking. After allowance for tobacco, alcohol and several other potential confounding factors, significant inverse association with the risk of oral and pharyngeal cancer was found for consumption of total green vegetables (OR 0.37) and total fruit (OR 0.34) with significant trends in risk Compared with alcohol drinkers of < 20 drinks/week and eating > 13 portions/week of total green vegetables, the OR for drinkers of > or = 20 drinks/week and eating < 7 portions/week of green vegetables was 15.44. Our study provides further support to the beneficial effect of high intake of vegetables and fruit, particularly in heavy smokers and alcohol drinkers.
1996年至1999年在意大利东北部开展了一项病例对照研究，分析了饮食与口腔和咽癌风险之间的关系。病例为132例患者（包括33名女性），患有新诊断的、经组织学确诊的口腔或咽癌；对照为148名因与吸烟或饮酒无关的急性疾病入院的受试者（包括45名女性）。在考虑烟草、酒精及其他一些潜在混杂因素后，发现总绿色蔬菜摄入量（比值比0.37）和总水果摄入量（比值比0.34）与口腔和咽癌风险呈显著负相关，且风险存在显著趋势。与每周饮酒少于20杯且每周食用超过13份总绿色蔬菜的饮酒者相比，每周饮酒≥20杯且每周食用少于7份绿色蔬菜的饮酒者的比值比为15.44。我们的研究进一步支持了高摄入蔬菜和水果的有益作用，尤其是在重度吸烟者和饮酒者中。
