白种人群脉络膜色素沉着与后葡萄膜黑色素瘤之间的关联。
Association between choroidal pigmentation and posterior uveal melanoma in a white population.
作者信息
Harbour J W, Brantley M A, Hollingsworth H, Gordon M
机构信息
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8069, 660 S. Euclid Avenue, St Louis, MO 63110, USA.
出版信息
Br J Ophthalmol. 2004 Jan;88(1):39-43. doi: 10.1136/bjo.88.1.39.
BACKGROUND/AIMS: It is well known that light skin pigmentation is a risk factor for cutaneous melanoma. The aim of this study was to investigate the analogous association between choroidal pigmentation and posterior uveal melanoma.
METHODS
Cross sectional study of 65 consecutive patients diagnosed with posterior uveal melanoma (melanoma group) and 218 consecutive patients referred for general retinal evaluation (control group). All patients were white. A clinical grading system for estimating choroidal pigmentation was developed and histologically validated in seven patients.
RESULTS
Melanoma patients with light iris colour were significantly more likely to have darker choroidal pigmentation than controls (p = 0.005). Darker choroidal pigmentation was associated histologically with increased density of choroidal melanocytes (p = 0.005).
CONCLUSIONS
Increased choroidal pigmentation, as a result of an increase in the density of pigmented choroidal melanocytes, is not protective but may actually be a risk factor for the development of posterior uveal melanoma in white patients. This finding may have implications for understanding the pathogenesis of uveal melanoma.
背景/目的：众所周知，皮肤色素沉着浅是皮肤黑色素瘤的一个危险因素。本研究的目的是调查脉络膜色素沉着与后葡萄膜黑色素瘤之间的类似关联。
方法
对65例连续诊断为后葡萄膜黑色素瘤的患者（黑色素瘤组）和218例连续接受一般视网膜评估的患者（对照组）进行横断面研究。所有患者均为白人。开发了一种用于评估脉络膜色素沉着的临床分级系统，并在7例患者中进行了组织学验证。
结果
虹膜颜色浅的黑色素瘤患者比对照组更有可能有更深的脉络膜色素沉着（p = 0.005）。组织学上，更深的脉络膜色素沉着与脉络膜黑素细胞密度增加有关（p = 0.005）。
结论
脉络膜色素沉着增加是由于色素性脉络膜黑素细胞密度增加所致，它并无保护作用，实际上可能是白人患者发生后葡萄膜黑色素瘤的一个危险因素。这一发现可能对理解葡萄膜黑色素瘤的发病机制有影响。
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