Holly E A, Aston D A, Ahn D K, Smith A H
Department of Epidemiology and Biostatics, School of Medicine, University of California San Francisco 94109-5453, USA.
Epidemiology. 1996 Jan;7(1):55-61. doi: 10.1097/00001648-199601000-00010.
We conducted a case-control study in the western United States to determine the relation between occupations or chemical exposures and increased risk of uveal melanoma. Among men (221 patients, 447 controls), we found increased risks for occupational groups who had intense exposure to ultraviolet light [odds ratio (OR) = 3.0; 95% confidence interval (CI) = 1.2-7.8], welding exposure (OR = 2.2; 95% CI = 1.3-3.5), and asbestos exposure (OR = 2.4; 95% CI = 1.5-3.9 for most likely exposed). The highest odds ratio was for the small number of men (nine cases, three controls) who were chemists, chemical engineers, and chemical technicians (OR = 5.9; 95% CI = 1.6-22.7). Odds ratios also were elevated for exposures to antifreeze, formaldehyde, pesticides, and carbon tetrachloride, but these findings, based on recall of specific chemical exposures, are more subject to recall bias than the findings based on occupational groups.
我们在美国西部开展了一项病例对照研究，以确定职业或化学物质暴露与葡萄膜黑色素瘤风险增加之间的关系。在男性中（221例患者，447例对照），我们发现强烈暴露于紫外线的职业群体风险增加[比值比（OR）=3.0；95%置信区间（CI）=1.2 - 7.8]，焊接暴露（OR = 2.2；95% CI = 1.3 - 3.5），以及石棉暴露（最可能暴露者的OR = 2.4；95% CI = 1.5 - 3.9）。比值比最高的是少数男性（9例病例，3例对照），他们是化学家、化学工程师和化学技术员（OR = 5.9；95% CI = 1.6 - 22.7）。接触防冻液、甲醛、杀虫剂和四氯化碳的比值比也有所升高，但这些基于对特定化学物质暴露回忆的结果，比基于职业群体的结果更容易受到回忆偏倚的影响。
