Chipman M L, Macdonald S, Mann R E
Department of Public Health Sciences, University of Toronto, Ontario, Canada.
Inj Prev. 2003 Dec;9(4):343-8. doi: 10.1136/ip.9.4.343.
To compare associations of alcohol, cannabis, and cocaine abuse and traffic crash risk for "at fault" crashes and all crashes.
A historical cohort study.
Toronto, Ontario. Patients or subjects: Subjects beginning treatment at the Centre for Addictions and Mental Health (CAMH) in 1994 for abuse of alcohol, cannabis, cocaine, and all combinations of these substances (n = 590, with 411 drivers). A control group consisted of 518 records from the Ontario registry of registered drivers, frequency matched for age and sex and residence.
CAMH subjects took part in therapeutic programs. Pre-intervention (11 115 driver-years) and post-intervention intervals (8550 driver-years) were defined and compared.
Crash and collision rates, adjusted relative risks (ARRs) of crash involvement and of "at fault" crashes were computed using Poisson regression to control for variations in time at risk, age, and sex of participants.
Pre-treatment, significant ARRs of 1.49 to 1.79 for all crashes were found for abusers of cannabis, cocaine, or a combination. ARRs increased by 10%-15% for "at fault" crashes. Post-treatment, all associations were very modest for all abuse types. Only younger and male drivers had a significantly increased risk, which was stronger for "at fault" than for all crashes.
Abuse of cannabis and cocaine pre-treatment was more strongly related to "at fault" crashes than to all crashes. Interaction between these substances means that the effects of combined abuse cannot be predicted from simple main effects.
比较酒精、大麻和可卡因滥用与“有过错”撞车事故及所有撞车事故的交通撞车风险之间的关联。
一项历史性队列研究。
安大略省多伦多市。患者或受试者:1994年开始在成瘾与心理健康中心(CAMH)接受酒精、大麻、可卡因及这些物质的所有组合滥用治疗的受试者(n = 590,其中411名驾驶员)。对照组由安大略省注册驾驶员登记处的518条记录组成,按年龄、性别和居住地进行频率匹配。
CAMH受试者参加治疗项目。定义并比较干预前(11115驾驶员年)和干预后间隔(8550驾驶员年)。
使用泊松回归计算撞车和碰撞率、撞车事故参与及“有过错”撞车事故的调整相对风险(ARR),以控制参与者的风险暴露时间、年龄和性别的差异。
治疗前,大麻、可卡因或两者组合滥用者的所有撞车事故的显著ARR为1.49至1.79。“有过错”撞车事故的ARR增加了10%-15%。治疗后,所有滥用类型的所有关联都非常适度。只有年轻男性驾驶员的风险显著增加,“有过错”撞车事故的风险比所有撞车事故的风险更强。
治疗前大麻和可卡因滥用与“有过错”撞车事故的关联比与所有撞车事故的关联更强。这些物质之间的相互作用意味着无法从简单的主效应预测联合滥用的影响。