逆转录病毒通过Toll样受体4依赖性方式激活树突状细胞
Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus.
作者信息
Burzyn Dalia, Rassa John C, Kim David, Nepomnaschy Irene, Ross Susan R, Piazzon Isabel
机构信息
División Medicina Experimental, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.
出版信息
J Virol. 2004 Jan;78(2):576-84. doi: 10.1128/jvi.78.2.576-584.2004.
Abstract
Mouse mammary tumor virus (MMTV) is a milk-borne retrovirus that exploits the adaptive immune system. It has recently been shown that MMTV activates B cells via Toll-like receptor 4 (TLR4), a molecule involved in innate immune responses. Here, we show that direct virus binding to TLR4 induced maturation of bone marrow-derived dendritic cells and up-regulated expression of the MMTV entry receptor (CD71) on these cells. In vivo, MMTV increased the number of dendritic cells in neonatal Peyer's patches and their expression of CD71; both these effects were dependent on TLR4. Thus, retroviral signaling through TLRs plays a critical role in dendritic-cell participation during infection.
摘要
小鼠乳腺肿瘤病毒（MMTV）是一种通过乳汁传播的逆转录病毒，它利用适应性免疫系统。最近研究表明，MMTV通过Toll样受体4（TLR4）激活B细胞，TLR4是一种参与先天免疫反应的分子。在此，我们发现病毒直接与TLR4结合可诱导骨髓来源的树突状细胞成熟，并上调这些细胞上MMTV进入受体（CD71）的表达。在体内，MMTV增加了新生派尔集合淋巴结中树突状细胞的数量及其CD71的表达；这两种效应均依赖于TLR4。因此，通过Toll样受体的逆转录病毒信号传导在感染过程中树突状细胞的参与中起关键作用。
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