Lukasik Victoria M, Gillies Robert J
Department of Anesthesiology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA.
NMR Biomed. 2003 Dec;16(8):459-67. doi: 10.1002/nbm.836.
Almost all animal patients, including research subjects, presented for MRI/MRS studies are anesthetized. As MR moves rapidly beyond simple anatomic studies, becoming a powerful tool for defining physiologic processes, it is imperative that investigators become familiar with the physiologic effects of the anaesthetic drugs. This decreases confounding variables, making data interpretation more accurate and more applicable to future uses. This article is intended to be a basic resource for investigators wishing to increase their understanding of the anesthetic drugs. The following is a general discussion describing the mechanism of action and physiologic effects of the more common anaesthetic drugs used in laboratory animals. A dosing table of common anaesthetics and analgesics used in mice and rats is included because these two species comprise a great majority of MRI/MRS research subjects.
几乎所有接受MRI/MRS研究的动物患者，包括研究对象，都要进行麻醉。随着磁共振成像（MR）迅速超越简单的解剖学研究，成为定义生理过程的强大工具，研究人员必须熟悉麻醉药物的生理效应。这可以减少混杂变量，使数据解释更准确，并更适用于未来的应用。本文旨在为希望加深对麻醉药物理解的研究人员提供一个基础资源。以下是一个一般性讨论，描述了实验动物中使用的更常见麻醉药物的作用机制和生理效应。文中还包括了小鼠和大鼠常用麻醉剂和镇痛药的剂量表，因为这两个物种占MRI/MRS研究对象的绝大多数。
