小型啮齿动物在磁共振成像期间的麻醉

Anaesthesia of small rodents during magnetic resonance imaging.

作者信息

Hanusch C, Hoeger S, Beck G C

机构信息

Clinic for Anaesthesiology and Intensive Care Medicine, University Hospital of Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

出版信息

Methods. 2007 Sep;43(1):68-78. doi: 10.1016/j.ymeth.2007.05.009.

DOI:10.1016/j.ymeth.2007.05.009

PMID:17720565

Abstract

The use of experimental animals for magnetic resonance studies requires anaesthesia to provide immobility and acquire signals with minimal stress and maximal reproducibility. However, the conduct of anaesthesia within a magnetic resonance imaging (MRI) suite implicates many problems, because most of the anaesthetic and monitoring equipment contains ferromagnetic substances. To decrease disturbances during anaesthesia and make data interpretation more accurate, it is mandatory that investigators become familiar with methods and physiologic effects of anaesthesia under these special conditions. This article is intended to give an overview of anaesthetic medication, administration routes and practical instructions for anaesthesia in small rodents during MRI.

摘要

将实验动物用于磁共振研究时，需要进行麻醉以确保动物保持静止，从而在最小应激和最大程度可重复性的条件下采集信号。然而，在磁共振成像（MRI）设备中实施麻醉存在诸多问题，因为大多数麻醉和监测设备都含有铁磁性物质。为了减少麻醉期间的干扰并使数据解读更加准确，研究人员必须熟悉在这些特殊条件下的麻醉方法及其生理效应。本文旨在概述小型啮齿动物在MRI检查期间的麻醉用药、给药途径及实际操作指南。