Rosenfeld C R, Barton M D, Meschia G
Am J Obstet Gynecol. 1976 Jan 15;124(2):156-63. doi: 10.1016/s0002-9378(16)33292-6.
Seven pregnant ewes ranging from 85 to 140 days of gestation were infused with systemic doses of epinephrine and uterine arterial flow dose-response curves were determined. With a constant systemic infusion of epinephrine at a mean rate of 0.29 +/- 0.03 mug/Kg.-min., and the radionuclide lebeled microsphere method to measure arterial blood flow, a 38.5 per cent decrease in total uterine arterial blood flow was demonstrated while systemic pressure was unaltered. At this dose the reduction in endometrial blood flow was significantly greater (-58.7 per cent) than that in either the myometrium (-36.9 per cent) or placental cotyledons (-34.5 per cent) (p less than 0.025 and less than 0.005, respectively). There also occurred a decrease in blood flow to the mammary gland and the pancreas, whereas increased in blood flow to the skeletal muscle, adipose tissue, and spleen were documented. It is evident from this study that during the period of ovine pregnancy investigated, the vascular bed of all tissues comprising the pregnant uterus, including the placental cotyledons, are sensitive to the vasoconstrictive effects of epinephrine.
对7只妊娠85至140天的母羊静脉注射肾上腺素，并测定子宫动脉血流剂量反应曲线。以平均速率0.29±0.03微克/千克·分钟持续静脉输注肾上腺素，并采用放射性核素标记微球法测量动脉血流，结果显示子宫总动脉血流减少了38.5%，而全身血压未发生改变。在此剂量下，子宫内膜血流的减少幅度（-58.7%）显著大于子宫肌层（-36.9%）或胎盘小叶（-34.5%）（分别为p<0.025和p<0.005）。乳腺和胰腺的血流也出现减少，而骨骼肌、脂肪组织和脾脏的血流则增加。从这项研究可以明显看出，在所研究的绵羊妊娠期内，构成妊娠子宫的所有组织，包括胎盘小叶的血管床，对肾上腺素的血管收缩作用敏感。
