Wedemeyer H, Cornberg M, Tegtmeyer B, Frank H, Tillmann H L, Manns M P
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany.
Clin Microbiol Infect. 2004 Jan;10(1):70-2. doi: 10.1111/j.1469-0691.2004.00771.x.
Recovery from hepatitis B virus (HBV) infection is associated with the presence of antibodies against HBV surface (HBs) antigen and HBV core (HBc) antigen. However, anti-HBs antibodies are lost in many cases, and only anti-HBc antibodies persist. A higher frequency of the anti-HBc-alone pattern has been demonstrated for anti-hepatitis C virus (HCV)-positive patients. In this report, 1126 anti-HCV-positive/anti-HBc-positive patients were studied, and the role of HCV replication in influencing the presence or absence of anti-HBs antibodies was investigated. The anti-HBc-alone phenotype was significantly more frequent in HCV-viraemic than in HCV-recovered patients. This finding represents new information regarding the immunopathogenesis of chronic HCV infection and supports previous data indicating impaired humoral immune responses in HCV infection.
从乙型肝炎病毒（HBV）感染中恢复与存在针对HBV表面（HBs）抗原和HBV核心（HBc）抗原的抗体有关。然而，在许多情况下抗-HBs抗体消失，仅抗-HBc抗体持续存在。抗丙型肝炎病毒（HCV）阳性患者中单独抗-HBc模式的频率更高。在本报告中，研究了1126例抗-HCV阳性/抗-HBc阳性患者，并调查了HCV复制在影响抗-HBs抗体存在与否中的作用。HCV病毒血症患者中单独抗-HBc表型的频率显著高于HCV康复患者。这一发现代表了关于慢性HCV感染免疫发病机制的新信息，并支持先前表明HCV感染中体液免疫反应受损的数据。
