Bertrams J
Boll Ist Sieroter Milan. 1978 Jan 31;56(6):506-15.
In the HLA complex it is evident that some antigens occur rather frequently, while others are rare. A statistically significant increase or decrease of any of these antigens in a given number of patients suffering from the same disease therefore suggests an association between such a disease and the HLA-system. In this study the Author compared the HLA antigen frequencies of 1.000 M.S. patients and 1.000 healthy controls, tissue typed during the same time period by the identical antiserum-set.
在HLA复合体中，很明显某些抗原出现的频率相当高，而其他抗原则很罕见。因此，在一定数量患同一种疾病的患者中，任何一种此类抗原在统计学上出现显著增加或减少，都表明该疾病与HLA系统之间存在关联。在本研究中，作者比较了1000例多发性硬化症患者和1000例健康对照者的HLA抗原频率，这些样本在同一时期使用相同的抗血清组进行组织分型。
