Sandqvist Anton, Sistonen Lea
Turku Centre for Biotechnology, BioCity, P.O. Box 123, FIN-20521 Turku, Finland.
J Cell Biol. 2004 Jan 5;164(1):15-7. doi: 10.1083/jcb.200311102.
Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites, a heterochromatic region that has been considered silent (Jolly et al., 2004). These intriguing findings will certainly give the research of these structures a new twist.
核应激颗粒是在热休克和其他应激刺激下形成的亚核区室。尽管已经鉴定出核应激颗粒的许多成分，包括热休克因子1（HSF1）和前体mRNA加工因子，但其功能仍然是个谜。本期的一篇论文描述了核应激颗粒靶位点之一（一个被认为是沉默的异染色质区域）的应激诱导转录激活（乔利等人，2004年）。这些有趣的发现必将为这些结构的研究带来新的转折。
