严重充血性心力衰竭患者尿中6-硫酸氧褪黑素水平较低。
Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure.
作者信息
Girotti Luis, Lago Manuel, Ianovsky Oscar, Elizari Marcelo V, Dini Andrés, Pérez Lloret Santiago, Albornoz Liliana E, Cardinali Daniel P
机构信息
División Cardiología, Hospital Ramos Mejía, Buenos Aires, Argentina.
出版信息
Endocrine. 2003 Dec;22(3):245-8. doi: 10.1385/ENDO:22:3:245.
OBJECTIVE
To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF).
METHODS
Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with hepatic or renal failure were excluded from the sample. Data were analyzed by the Mann-Whitney test and regression analysis.
RESULTS
6-Sulfatoxymelatonin levels were significantly lower in CHF patients than controls (median 2.6 vs 6.02 microg, p < 0.0001). This decrease was observed regardless of beta-adrenergic blocker or benzodiazepine medication. A significant decrease in 6-sulfatoxymelatonin excretion occurred with age. There were no significant differences in urinary 6-sulfatoxymelatonin levels between chronic and acute CHF patients.
CONCLUSIONS
The results suggest that circulating melatonin levels are low in patients with CHF. Such a decrease may precede aggravation of heart failure.
目的
评估因充血性心力衰竭（CHF）入院患者的尿6-硫酸氧褪黑素排泄情况。
方法
采用特异性放射免疫分析法，对33例住院CHF患者和146例健康门诊志愿者测定尿6-硫酸氧褪黑素。样本排除了肝或肾功能衰竭患者。数据采用曼-惠特尼检验和回归分析。
结果
CHF患者的6-硫酸氧褪黑素水平显著低于对照组（中位数2.6对6.02微克，p<0.0001）。无论是否使用β-肾上腺素能阻滞剂或苯二氮䓬类药物，均观察到这种降低。6-硫酸氧褪黑素排泄随着年龄显著降低。慢性和急性CHF患者的尿6-硫酸氧褪黑素水平无显著差异。
结论
结果表明CHF患者的循环褪黑素水平较低。这种降低可能在心力衰竭加重之前出现。
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