Joffe Hadine, Cohen Lee S, Harlow Bernard L
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC, Boston, MA 02114, USA.
Am J Obstet Gynecol. 2003 Dec;189(6):1523-30. doi: 10.1016/s0002-9378(03)00927-x.
The purpose of this study was to estimate risk factors for the deterioration and improvement of premenstrual mood disturbance with oral contraceptive pill use.
Predictors of the deleterious and beneficial effects of oral contraceptive pill use on premenstrual mood were analyzed with the use of logistic regression in a nested case-control study within a community-based cohort of 976 premenopausal women in Massachusetts.
Of 658 women who were using oral contraceptive pills, 16.3% of the women reported oral contraceptive pill-related premenstrual mood deterioration, and 12.3% of the women reported premenstrual mood improvement. In adjusted models, previous depression was the only significant predictor of mood deterioration (odds ratio, 2.0; 95% CI, 1.1-3.8); early-onset premenstrual mood disturbance and dysmenorrhea were significant predictors of oral contraceptive pill-related mood improvement (odds ratio, 3.1 [95% CI, 1.9-5.2] and odds ratio, 2.3 [95% CI, 1.4-3.9], respectively).
Oral contraceptive pills do not influence premenstrual mood in most women. Premenstrual mood is most likely to deteriorate in women with a history of depression and to improve in women with early-onset premenstrual mood disturbance or dysmenorrhea.
本研究旨在评估口服避孕药使用过程中经前情绪障碍恶化和改善的风险因素。
在马萨诸塞州一个基于社区的976名绝经前女性队列的巢式病例对照研究中，采用逻辑回归分析口服避孕药对经前情绪有害和有益影响的预测因素。
在658名使用口服避孕药的女性中，16.3%的女性报告有与口服避孕药相关的经前情绪恶化，12.3%的女性报告经前情绪改善。在调整模型中，既往抑郁是情绪恶化的唯一显著预测因素（比值比，2.0；95%可信区间，1.1 - 3.8）；早发性经前情绪障碍和痛经是口服避孕药相关情绪改善的显著预测因素（比值比分别为3.1 [95%可信区间，1.9 - 5.2]和2.3 [95%可信区间，1.4 - 3.9]）。
口服避孕药对大多数女性的经前情绪没有影响。有抑郁病史的女性经前情绪最有可能恶化，而有早发性经前情绪障碍或痛经的女性经前情绪最有可能改善。
