Wolkoff Peder, Skov Peder, Franck Carsten, Petersen Lisbeth N
Department of Indoor Climate, National Institute of Occupational Health, Copenhagen, Denmark.
Scand J Work Environ Health. 2003 Dec;29(6):411-30. doi: 10.5271/sjweh.748.
The study reviews eye irritation using a multidisciplinary approach. Potential risk factors and objective gender differences are identified, and possible hypotheses for eye irritation caused by indoor air pollution are discussed. Eye irritation depends somewhat on destabilization of the outer-eye tear film. An integrated physiological risk model with blink frequency, destabilization, and break-up of the eye tear film as inseparable phenomena may explain eye irritation among office workers in terms of occupational, climate, and eye-related physiological risk factors. Certain volatile organic compounds that are both chemically reactive and airway irritants may cause eye irritation. If airborne particles alone should destabilize the tear film and cause eye irritation, their content of surface-active compounds must be high. Personal factors (eg, use of contact lenses, eye make-up, and certain medication) may also affect destabilization of the tear film and possibly result in more eye symptoms.
该研究采用多学科方法对眼部刺激进行了综述。确定了潜在风险因素和客观的性别差异，并讨论了由室内空气污染导致眼部刺激的可能假设。眼部刺激在一定程度上取决于眼表泪膜的不稳定。一个将眨眼频率、不稳定和眼泪膜破裂视为不可分割现象的综合生理风险模型，或许可以从职业、气候和与眼睛相关的生理风险因素方面解释办公室工作人员的眼部刺激问题。某些具有化学反应性且为气道刺激物的挥发性有机化合物可能会导致眼部刺激。如果仅空气传播颗粒就会使泪膜不稳定并导致眼部刺激，那么它们表面活性化合物的含量必须很高。个人因素（如使用隐形眼镜、眼部化妆和某些药物）也可能影响泪膜的不稳定，并可能导致更多的眼部症状。
