Ashkenazi J, Yoeli R, Orvieto R, Shalev J, Ben-Rafael Z, Bar-Hava I
Department of Obstetrics and Gynecology, Rabin Medical Center, Golda Campus, Petah Tikva, Israel.
Fertil Steril. 2000 Nov;74(5):936-40. doi: 10.1016/s0015-0282(00)01549-1.
The aim of this study was to evaluate the consecutive transfer approach of early embryos and blastocyst(s).
Case-control study.
Public assisted reproduction technology unit.
PATIENT(S): The study population consisted of three groups. In Group 1, a double transfer was performed on 136 consecutive women, that is, a standard transfer of embryos on day 2 or 3, and a second transfer of a blastocyst(s). In Group 2, an early transfer of only two embryos and a second transfer of one blastocyst were performed on 29 women from group 1 who had more than three high-quality embryos available for early transfer. In Group 3, a single early transfer was performed on 139 consecutive women who received three high-quality embryos (controls).
INTERVENTION(S): Early embryo transfer, extended culture of the spare embryos, and a second transfer of a blastocyst(s).
MAIN OUTCOME MEASURE(S): Implantation and pregnancy rates. RESULTSs): No differences were detected among the three groups in either pregnancy or implantation rates (pregnancy: 36.8%, 41.4%, and 37.4%, respectively; implantation: 14.6%, 19.9%, and 19.8%, respectively).
CONCLUSION(S): The double (consecutive) transfer of early embryos and blastocyst(s) does not offer any advantage over the traditional early transfer. This may be from the adverse effect of the second transfer on the implantation process.
本研究旨在评估早期胚胎和囊胚的连续移植方法。
病例对照研究。
公共辅助生殖技术单位。
研究人群包括三组。第1组，对136名连续的女性进行了两次移植，即第2天或第3天进行标准胚胎移植，第二次移植囊胚。第2组，对第1组中29名有三个以上优质胚胎可供早期移植的女性进行仅两个胚胎的早期移植和一个囊胚的第二次移植。第3组，对139名连续接受三个优质胚胎的女性进行单次早期移植（对照组）。
早期胚胎移植、备用胚胎的延长培养以及囊胚的第二次移植。
着床率和妊娠率。
三组的妊娠率或着床率均未检测到差异（妊娠率：分别为36.8%、41.4%和37.4%；着床率：分别为14.6%、19.9%和19.8%）。
早期胚胎和囊胚的双重（连续）移植并不比传统的早期移植有任何优势。这可能是由于第二次移植对着床过程产生的不利影响。
