Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan
Department of Critical Care Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Antimicrob Agents Chemother. 2019 Apr 25;63(5). doi: 10.1128/AAC.02256-18. Print 2019 May.
infections are uncommon, and previous studies have revealed that is frequently misidentified as We aimed to explore the differences in clinical manifestations and antimicrobial susceptibility patterns between and The database of a clinical microbiology laboratory was searched to identify patients with infections between 2005 and 2017. Species were reidentified using 16S rRNA gene sequencing, and patients with and infections were included in the study. A total of 42 and 84 isolates were collected from consecutive patients. A significant increase in incidence was observed. was significantly more associated with bacteremia than Patients with infections had more comorbidities of malignancy and liver cirrhosis than those with infections. The overall case fatality rate was 19.8%. Independent risk factors for mortality were female sex and infection. These isolates were most susceptible to minocycline (73%), followed by trimethoprim-sulfamethoxazole (47.6%), tigecycline (34.1%), and levofloxacin (32.5%). exhibited a significantly higher rate of susceptibility than to piperacillin, piperacillin-tazobactam, ceftazidime, tigecycline, and levofloxacin. Alterations in DNA gyrase subunit A were identified to be associated with fluoroquinolone resistance in No nonsynonymous substitutions were observed in the quinolone resistance-determining regions (QRDRs) of Differences in epidemiology, clinical manifestations, and antimicrobial susceptibility patterns exist between and Additional investigations are needed to explore the significance of these differences.
感染并不常见，先前的研究表明， 经常被错误地鉴定为 。我们旨在探讨 和 之间临床表现和抗菌药物敏感性模式的差异。从 2005 年至 2017 年，检索临床微生物学实验室的数据库以鉴定 感染患者。使用 16S rRNA 基因测序重新鉴定种属，将 和 感染患者纳入研究。共收集了 42 株 和 84 株连续患者分离株。 发病率显著增加。 与菌血症的相关性明显高于 。 感染患者的合并症恶性肿瘤和肝硬化比 感染患者更多。总病死率为 19.8%。死亡率的独立危险因素是女性和 感染。这些分离株对米诺环素（73%）最敏感，其次是复方磺胺甲恶唑（47.6%）、替加环素（34.1%）和左氧氟沙星（32.5%）。 对哌拉西林、哌拉西林-他唑巴坦、头孢他啶、替加环素和左氧氟沙星的敏感性明显高于 。在 中发现 DNA 回旋酶亚单位 A 的改变与氟喹诺酮类药物耐药有关。 在喹诺酮类药物耐药决定区（QRDRs）中未观察到非同义取代。 和 之间在流行病学、临床表现和抗菌药物敏感性模式方面存在差异。需要进一步研究以探讨这些差异的意义。
